Germinal centre B cells (GCBs) are strictly localized to lymphoid organs, unlike those of GCB-like diffuse large B cell lymphoma (GCB-DLBCL). Muppidi et al. found that GCB-DLBCL-associated inactivating mutations in GNA13, which encodes the guanine nucleotide binding protein Gα13, allow AKT activation and cell migration. Loss of Gα13 in mice caused dissemination of GCBs, and these mice developed GCB-derived lymphoma. GCB-DLBCL-associated mutations were also found in ARHGEF1, a Gα13 effector, the loss of which also caused GCB dissemination in mice, indicating that altered Gα13 signalling promotes GCB dissemination.
References
Muppidi, J. R. et al. Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma. Nature http://dx.doi.org/10.1038/nature13765 (2014)
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Alderton, G. Release the B cell. Nat Rev Cancer 14, 707 (2014). https://doi.org/10.1038/nrc3856
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DOI: https://doi.org/10.1038/nrc3856
