In Figure 2 on page 30 of this Review the oestrogen receptor (ER) dimer on the left-hand side was erroneously shown to simultaneously bind to SP1 and AP1 transcription factors. The ubiquitylated ER that enters the proteasome is most likely an unliganded monomer and not an oestrogen-bound ER dimer as originally shown in the figure. Tyrosine phosphorylation of ER was shown as being Y357 instead of Y537 and the text in the central blue box which stated “Dual role co-activators mediate ER degradation coupled to target gene activation” should have read “Dual role ER co-activators promote ER target gene activation coupled to ER proteolysis”. All of these corrections have been made online.
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The online version of the original article can be found at 10.1038/nrc3622
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Zhou, W., Slingerland, J. Erratum: Links between oestrogen receptor activation and proteolysis: relevance to hormone-regulated cancer therapy. Nat Rev Cancer 14, 146 (2014). https://doi.org/10.1038/nrc3671
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DOI: https://doi.org/10.1038/nrc3671
