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The developing role of receptors and adaptors

Nature Reviews Cancer volume 6, pages 403–409 (2006)Cite this article

Abstract

The response of a cell to the myriad of signals that it receives is varied, and it is dependent on many different factors. The most-studied responses involve growth-factor signalling and these signalling cascades have become key targets for cancer therapy. Recent reports have indicated that growth-factor receptors and associated adaptors can accumulate in the nucleus. Are there novel functions for these proteins that might affect our understanding of their role in cancer and have implications for drug resistance?

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Figure 1: ERBB trafficking.
Figure 2: Putative mechanisms for the movement of receptor tyrosine kinases (RTKs) into the nucleus.

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Acknowledgements

The authors gratefully acknowledge the advice and support of D. E. Neal, T. Ross and M.-C. Hung as well as Cancer Research UK and the NCRI/ProMPT prostate cancer research collaborative.

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  1. the Department of Oncology, CRUK Uro-Oncology Group, University of Cambridge, c/o Hutchison/MRC Cancer Research Centre, Addenbrookes Hospital, Hills Road, Cambridge, CB2 2XZ, UK

    Charles Massie & Ian G. Mills

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Correspondence to Ian G. Mills.

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Massie, C., Mills, I. The developing role of receptors and adaptors. Nat Rev Cancer 6, 403–409 (2006). https://doi.org/10.1038/nrc1882

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