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Integrated global profiling of cancer

Nature Reviews Cancer volume 4, pages 638–644 (2004)Cite this article

Abstract

Tumours are complex biological systems. No single type of molecular approach fully elucidates tumour behaviour, necessitating analysis at multiple levels encompassing genomics and proteomics. Integrated data sets are required to fully determine the contributions of genome alterations, host factors and environmental exposures to tumour growth and progression, as well as the consequences of interactions between malignant or premalignant cells and their microenvironment. The sheer amount and heterogeneous nature of data that need to be collected and integrated are daunting, but effort has already begun to address these obstacles.

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Figure 1: Numerous components must be integrated to study the molecular basis of human cancer.
Figure 2: Integrated gene-expression profile of neoplastic transformation.
Figure 3: Path from data collection and integration to hypothesis testing.

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Authors and Affiliations

  1. the Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M5-C800, PO Box 19024, Seattle, 98109, Washington, USA

    Samir Hanash

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  1. Samir Hanash
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The author declares no competing financial interests.

Related links

Related links

DATABASES

Cancer.gov

breast cancer

lung cancer

ovarian cancer

Entrez Gene

CDK4

CRK

cyclin D1

ERBB2

LMYC

phosphoglycerate kinase 1

TP53

TSC1

TSC2

FURTHER INFORMATION

ArrayExpress

Biocarta

Biomolecular Interaction Database

CaCORE

Cancer Biomedical Informatics Grid

Cancer Genome Anatomy Project

Cytoscape

Database of Interacting Proteins

DBCAT, The Public Catalog of Databases

Director's Challenge initiative

Early Detection Research Network

European Bioinformatics Institute

Gene Expression Omnibus

GenMAPP

Gene Ontology Consortium

GoMiner

Human Gene Expression Index

Human Protein Reference Database

International HapMap Project

InterPro

Kinase Pathway Database

Kyoto Encyclopedia of Genes and Genomes

Mouse Models of Human Cancers Consortium

National Cancer Institute Gene Expression Data Portal

National Cancer Research Institute Cancer Informatics web site

National Center for Biotechnology Information

National Institutes of Health Roadmap

Stanford Microarray Database

The Genome Database

Therapeutic Target Database

Transpath

UniProt/Swiss-Prot

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Hanash, S. Integrated global profiling of cancer. Nat Rev Cancer 4, 638–644 (2004). https://doi.org/10.1038/nrc1414

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