Obesity is associated with prostate cancer that is locally disseminated into the periprostatic adipose tissue (PPAT) that surrounds the prostate gland and Laurent et al. have found a possible explanation. Adipocytes secrete chemokine (C-C motif) ligand 7 (CCL7), which diffuses from PPAT into the prostate peripheral zone. This stimulates the migration of chemokine (C-C motif) receptor 3 (CCR3)-expressing tumour cells. This chemotaxis is increased in obesity and can be prevented when CCR3–CCL7 is blocked. CCR3 expression in human prostate cancer cells is associated with aggressive disease, local dissemination and higher risk of biochemical recurrence (denoted by changes in prostate-specific antigen (PSA) levels).
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11 November 2016
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References
Laurent, V. et al. Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity. Nat. Commun. 7, 10230 (2016)
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Alderton, G. Obesity promotes prostate cancer invasion. Nat Rev Cancer 16, 70 (2016). https://doi.org/10.1038/nrc.2016.129
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DOI: https://doi.org/10.1038/nrc.2016.129
