Abstract
We identified allele *2 in the HS1.2 enhancer of the Igh 3' regulatory region (3'RR-1) as a risk factor for systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and systemic sclerosis (SSc) (scleroderma). An NF-&x03BA;B binding site specific to allele *2 may contribute to the association of this allele with chronic inflammatory autoimmune diseases.
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Frezza, D., Gremese, E., Giambra, V. et al. Association of autoimmune diseases to allele 2 of the 3' immuno-globulines HS1.2 enhancer bearing an NF-&x03BA;B binding site.. Nat Prec (2009). https://doi.org/10.1038/npre.2009.4102.1
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DOI: https://doi.org/10.1038/npre.2009.4102.1