Abstract
We developed a Bayesian hierarchical model to identify gene networks based on the similarity score generated from comparing the gene ontology fingerprints of gene pairs. Genes in this network were assumed to have similar biological functions that can be indicated by their ontology fingerprints. Our results indicate that different pathways show consistent score threshold that allow us to distinguish biological relevant gene—gene connections in the network.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Qin, T., Tsoi, L., Lawson, A. et al. A Bayesian Hierarchical Model to Derive Novel Gene Networks from Gene Ontology Fingerprints. Nat Prec (2009). https://doi.org/10.1038/npre.2009.3511.1
Received:
Accepted:
Published:
DOI: https://doi.org/10.1038/npre.2009.3511.1