Abstract
It has been proposed that functional modules are the fundamental units of cellular function. Methods to identify these modules have thus far relied on gene expression data or protein-protein interaction (PPI) data, but have a few limitations. We propose a new method, using biological pathway data to identify functional modules, that can potentially overcome these limitations. We also construct a network of these modules using functionally relevant PPI data. This network displays the flow and integration of information between modules and can be used to map cellular function.
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Zhao, S., Li, Y. Extracting Functional Modules from Biological Pathways. Nat Prec (2007). https://doi.org/10.1038/npre.2007.1457.1
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DOI: https://doi.org/10.1038/npre.2007.1457.1