Combinatorial Psycho-Pharmacological Approaches for the Treatment of Abnormal Aggression

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  1. , (2012). Doing anger differently: two controlled trials of percussion group psychotherapy for adolescent reactive aggression. J Adolesc 35: 843–853.

  2. , , , , , (2009). Burden and consequences of child maltreatment in high-income countries. Lancet 373: 68–81.

  3. Karpova NN, Pickenhagen A, Lindholm J, Tiraboschi E, Kulesskaya N, Agustsdottir A et al (2011). Fear erasure in mice requires synergy between antidepressant drugs and extinction training. Science334: 1731–1734..

  4. Langton LL, Truman JL (2014). Socio-emotional impact of violent crime. Bureau of Justice Statistics. Available at: .

  5. , , (2013). Excessive aggression as model of violence: a critical evaluation of current preclinical methods. Psychopharmacology 226: 445–458.

  6. Mikics E, Guirado R, Umemori J, Toth M, Biro L, Miskolczi C et al (2017). Social learning requires plasticity enhanced by fluoxetine through prefrontal Bdnf-TrkB signaling to limit aggression induced by post-weaning social isolation. Neuropsychopharmacology. (Advance online publication, 9 August 2017; doi:10.1038/npp.2017.142).

  7. , , , (2016). Suicidality and aggression during antidepressant treatment: systematic review and meta-analyses based on clinical study reports. BMJ 352: i65.

  8. , , , , (2008). Early social deprivation induces disturbed social communication and violent aggression in adulthood. Behav Neurosci 122: 849–854.

  9. Truman JL, Morgan RE (2016). Criminal victimization, 2015. Bureau of Justice Statistics. Available at: .

  10. , (2017). The programming of the social brain by stress during childhood and adolescence: from rodents to humans. Curr Top Behav Neurosci 30: 411–429.

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We thank Dr Yavin Shaham for insightful comments on a draft of this manuscript. The research was supported by the Intramural Research Program of NIDA and a National Institute of General Medical Sciences Postdoctoral Research Associate Grant 1FI2GM117583-01 (SAG), and KAKEN 17H04766, 15K12773 (AT).

Author information


  1. Neurobiology of Relapse Section, National Institute on Drug Abuse, Baltimore, MD, USA

    • Sam A Golden
  2. Laboratory of Behavioral Neuroendocrinology, University of Tsukuba, Tsukuba, Japan

    • Aki Takahashi


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Corresponding authors

Correspondence to Sam A Golden or Aki Takahashi.