Article | Published:

Multifunctional wearable devices for diagnosis and therapy of movement disorders

Nature Nanotechnology volume 9, pages 397404 (2014) | Download Citation

Abstract

Wearable systems that monitor muscle activity, store data and deliver feedback therapy are the next frontier in personalized medicine and healthcare. However, technical challenges, such as the fabrication of high-performance, energy-efficient sensors and memory modules that are in intimate mechanical contact with soft tissues, in conjunction with controlled delivery of therapeutic agents, limit the wide-scale adoption of such systems. Here, we describe materials, mechanics and designs for multifunctional, wearable-on-the-skin systems that address these challenges via monolithic integration of nanomembranes fabricated with a top-down approach, nanoparticles assembled by bottom-up methods, and stretchable electronics on a tissue-like polymeric substrate. Representative examples of such systems include physiological sensors, non-volatile memory and drug-release actuators. Quantitative analyses of the electronics, mechanics, heat-transfer and drug-diffusion characteristics validate the operation of individual components, thereby enabling system-level multifunctionalities.

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Acknowledgements

This work was supported by the Institute for Basic Science. This work was also supported by a grant (2013M3A6A5073180) from the Center for Advanced Soft Electronics under the Global Frontier Research Program of the Ministry of Science, ICT and Future Planning, Korea, and by a grant from the Basic Science Research Program of the National Research Foundation of Korea (NRF), funded by the Ministry of Science, ICT and Future Planning (2012R1A1A1004925). N.L. acknowledges startup funding from the Cockrell School of Engineering of the University of Texas at Austin. C.S.H. acknowledges support from the Global Research Laboratory Program (2012040157) through the NRF.

Author information

Author notes

    • Donghee Son
    •  & Jongha Lee

    These authors contributed equally to this work

Affiliations

  1. Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea

    • Donghee Son
    • , Jongha Lee
    • , Jaemin Kim
    • , Ji Eun Lee
    • , Changyeong Song
    • , Seok Joo Kim
    • , Dong Jun Lee
    • , Samuel Woojoo Jun
    • , Minjoon Park
    • , Jiho Shin
    • , Kyungsik Do
    • , Mincheol Lee
    • , Kwanghun Kang
    • , Taeghwan Hyeon
    •  & Dae-Hyeong Kim
  2. School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea

    • Donghee Son
    • , Jongha Lee
    • , Jaemin Kim
    • , Ji Eun Lee
    • , Changyeong Song
    • , Seok Joo Kim
    • , Dong Jun Lee
    • , Samuel Woojoo Jun
    • , Minjoon Park
    • , Jiho Shin
    • , Kyungsik Do
    • , Mincheol Lee
    • , Kwanghun Kang
    • , Taeghwan Hyeon
    •  & Dae-Hyeong Kim
  3. Center for Mechanics of Solids, Structures and Materials, Department of Aerospace Engineering and Engineering Mechanics, Texas Materials Institute, University of Texas at Austin, 210 E 24th Street, Austin, Texas 78712, USA

    • Shutao Qiao
    • , Shixuan Yang
    •  & Nanshu Lu
  4. MC10 Inc., 9 Camp Street, Cambridge, Massachusetts 02140, USA

    • Roozbeh Ghaffari
  5. WCU Hybrid Materials Program, Department of Materials Science and Engineering and Inter-university Semiconductor Research Center, Seoul National University, Seoul 151-744, Republic of Korea

    • Cheol Seong Hwang

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Contributions

D.S., J.L. and D-H.K. designed the experiments. D.S., J.L., S.Q., R.G., J.K., S.J.K., S.Y., C.S., J.E.L., D.J.L., S.W.J., M.P., J.S., K.D., M.L., K.K., C.S.H., N.L., T.H. and D-H.K. performed experiments and analysis. D.S., J.L., S.Q., J.L., R.G., J.K., C.S.H., N.L., T.H. and D-H.K. wrote the paper.

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Dae-Hyeong Kim.

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DOI

https://doi.org/10.1038/nnano.2014.38

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