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Molecular motors

Myosin shifts into reverse gear

A motor protein can be made to walk in either direction along a filamentous track by adjusting the concentration of calcium ions in the surrounding solution.

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Figure 1: Controlling the direction of myosin motors.

References

  1. Chen, L., Nakamura, M., Schindler, T. D., Parker, D. & Bryant, Z. Nature Nanotech. 7, 252–256 (2012).

    Article  CAS  Google Scholar 

  2. Sweeney, H. L. & Houdusse, A. Curr. Opin. Cell Biol. 19, 57–66 (2007).

    Article  CAS  Google Scholar 

  3. Holmes, K. C., Schröder, R. R., Sweeney, H. L. & Houdusse, A. Phil. Trans. R. Soc. Lond. B 359, 1819–1828 (2004).

    Article  CAS  Google Scholar 

  4. Ménétrey, J. et al. Nature 435, 779–785 (2005).

    Article  Google Scholar 

  5. Tsiavaliaris, G., Fujita-Becker, S. & Manstein, D. J. Nature 427, 558–561 (2004).

    Article  CAS  Google Scholar 

  6. Bryant, Z., Altman, D. & Spudich, J. A. Proc. Natl Acad. Sci. USA 104, 772–777 (2007).

    Article  CAS  Google Scholar 

  7. Liao, J. C., Elting, M. W., Delp, S. L., Spudich, J. A. & Bryant, Z. J. Mol. Biol. 392, 862–867 (2009).

    Article  CAS  Google Scholar 

  8. Trybus, K. M. et al. J. Biol. Chem. 282, 23316–23325 (2007).

    Article  CAS  Google Scholar 

  9. Wells, A. L. et al. Nature 401, 505–508 (1999).

    Article  CAS  Google Scholar 

  10. Levskaya, A., Weiner, O. D., Lim, W. A. & Voigt, C. A. Nature 461, 997–1001 (2009).

    Article  CAS  Google Scholar 

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Correspondence to Stefan Diez.

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Walter, W., Diez, S. Myosin shifts into reverse gear. Nature Nanotech 7, 213–214 (2012). https://doi.org/10.1038/nnano.2012.49

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