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Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation

Nature Neuroscience 9, 602–604 (2006) | Download Citation

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Abstract

Postnatal glutamatergic principal neuron synapses are typically presumed to express only calcium-impermeable (CI), GluR2-containing AMPARs under physiological conditions. Here, however, we demonstrate that long-term potentiation (LTP) in CA1 hippocampal pyramidal neurons causes rapid incorporation of GluR2-lacking calcium-permeable (CP)-AMPARs: CP-AMPARs are present transiently, being replaced by GluR2-containing AMPARs ∼25 min after LTP induction. Thus, CP-AMPARs are physiologically expressed at CA1 pyramidal cell synapses during LTP, and may be required for LTP consolidation.

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Acknowledgements

Supported by the Wellcome Trust (A.T., G.L.C. and J.T.R.I.), the Medical Research Council UK (G.L.C. and J.T.R.I.), the National Institute of Neurological Disorders and Stroke Intramural Program (J.T.R.I.) and the National Institute of Child Health and Human Development Intramural Program (K.A.P. and C.J.M.)

Author information

    • Karen Plant
    •  & Kenneth A Pelkey

    These authors contributed equally to this work.

Affiliations

  1. MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, Bristol BS8 1TD, UK.

    • Karen Plant
    • , Zuner A Bortolotto
    • , Daiju Morita
    • , Akira Terashima
    • , Graham L Collingridge
    •  & John T R Isaac

  2. Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, 35 Convent Drive, Bethesda, Maryland 20892, USA.

    • Kenneth A Pelkey
    •  & Chris J McBain

  3. Developmental Synaptic Plasticity Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive, Bethesda, Maryland 20892, USA.

    • Daiju Morita
    •  & John T R Isaac

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to John T R Isaac.

Supplementary information

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  1. 1.

    Supplementary Fig. 1

    LTP is NMDA receptor-dependent and PhTx blocks potentiated EPSCs when applied three minutes after LTP induction.

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    Supplementary Methods

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DOI

https://doi.org/10.1038/nn1678

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