Cajal, S.R.Y. Degeneration and Regeneration of the Nervous System. (Oxford University Press, London, 1928).
Christensen, M.D. & Hulsebosch, C.E. Chronic central pain after spinal cord injury. J. Neurotrauma 14, 517–537 (1997).
Cairns, D.M., Adkins, R.H. & Scott, M.D. Pain and depression in acute traumatic spinal cord injury: origins of chronic problematic pain? Arch. Phys. Med. Rehabil. 77, 329–35 (1996).
Bunge, R.P., Puckett, W.R. & Hiester, E.D. Observations on the pathology of several types of human spinal cord injury, with emphasis on the astrocyte response to penetrating injuries. Adv. Neurol. 72, 305–315 (1997).
Waxman, S.G. Demyelination in spinal cord injury. J. Neurol. Sci. 91, 1–14 (1989).
McDonald, J.W. et al. Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord. Nat. Med. 5, 1410–1412 (1999).
Hofstetter, C.P. et al. Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery. Proc. Natl. Acad. Sci. USA 99, 2199–2204 (2002).
Ogawa, Y. et al. Transplantation of in vitro-expanded fetal neural progenitor cells results in neurogenesis and functional recovery after spinal cord contusion injury in adult rats. J. Neurosci. Res. 69, 925–933 (2002).
Vroemen, M., Aigner, L., Winkler, J. & Weidner, N. Adult neural progenitor cell grafts survive after acute spinal cord injury and integrate along axonal pathways. Eur. J. Neurosci. 18, 743–751 (2003).
Lu, P., Jones, L.L., Snyder, E.Y. & Tuszynski, M.H. Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injury. Exp. Neurol. 181, 115–129 (2003).
Akiyama, Y. et al. Transplantation of clonal neural precursor cells derived from adult human brain establishes functional peripheral myelin in the rat spinal cord. Exp. Neurol. 167, 27–39 (2001).
Hao, J., Ebendal, T., Xu, X., Wiesenfeld-Hallin, Z. & Eriksdotter Jonhagen, M. Intracerebroventricular infusion of nerve growth factor induces pain-like response in rats. Neurosci. Lett. 286, 208–212 (2000).
Jubran, M. & Widenfalk, J. Repair of peripheral nerve transections with fibrin sealant containing neurotrophic factors. Exp. Neurol. 181, 204–212 (2003).
Eriksdotter Jonhagen, M. et al. Intracerebroventricular infusion of nerve growth factor in three patients with Alzheimer's disease. Dement. Geriatr. Cogn. Disord. 9, 246–257 (1998).
Nieto, M., Schuurmans, C., Britz, O. & Guillemot, F. Neural bHLH genes control the neuronal versus glial fate decision in cortical progenitors. Neuron 29, 401–413 (2001).
Sun, Y. et al. Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms. Cell 104, 365–376 (2001).
Spenger, C. et al. Functional MRI at 4.7 tesla of the rat brain during electric stimulation of forepaw, hindpaw, or tail in single- and multislice experiments. Exp. Neurol. 166, 246–253 (2000).
Hofstetter, C.P., Schweinhardt, P., Klason, T., Olson, L. & Spenger, C. Numb rats walk - a behavioural and fMRI comparison of mild and moderate spinal cord injury. Eur. J. Neurosci. 18, 3061–3068 (2003).
Coumans, J.V. et al. Axonal regeneration and functional recovery after complete spinal cord transection in rats by delayed treatment with transplants and neurotrophins. J. Neurosci. 21, 9334–9344 (2001).
Bradbury, E.J. et al. Chondroitinase ABC promotes functional recovery after spinal cord injury. Nature 416, 636–640 (2002).
Olson, L. Regeneration in the adult central nervous system: experimental repair strategies. Nat. Med. 3, 1329–1335 (1997).
Pearse, D.D. et al. cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury. Nat. Med. 10, 610–616 (2004).
Bareyre, F.M. et al. The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats. Nat. Neurosci. 7, 269–277 (2004).
Brown, A., Ricci, M.J. & Weaver, L.C. NGF message and protein distribution in the injured rat spinal cord. Exp. Neurol. 188, 115–127 (2004).
Averill, S., McMahon, S.B., Clary, D.O., Reichardt, L.F. & Priestley, J.V. Immunocytochemical localization of trkA receptors in chemically identified subgroups of adult rat sensory neurons. Eur. J. Neurosci. 7, 1484–1494 (1995).
Christensen, M.D. & Hulsebosch, C.E. Spinal cord injury and anti-NGF treatment results in changes in CGRP density and distribution in the dorsal horn in the rat. Exp. Neurol. 147, 463–475 (1997).
Hokfelt, T. et al. Calcitonin gene-related peptide in the brain, spinal cord, and some peripheral systems. Ann. NY Acad. Sci. 657, 119–134 (1992).
Willis, W.D. & Coggeshall, R.E. Sensory Mechanisms of the Spinal Cord. (Plenum, New York, 1991).
Bennett, A.D., Chastain, K.M. & Hulsebosch, C.E. Alleviation of mechanical and thermal allodynia by CGRP(8–37) in a rodent model of chronic central pain. Pain 86, 163–175 (2000).
Tomita, K., Moriyoshi, K., Nakanishi, S., Guillemot, F. & Kageyama, R. Mammalian achaete-scute and atonal homologs regulate neuronal versus glial fate determination in the central nervous system. EMBO J. 19, 5460–5472 (2000).
Guillemot, F. Vertebrate bHLH genes and the determination of neuronal fates. Exp. Cell Res. 253, 357–364 (1999).
Zirlinger, M., Lo, L., McMahon, J., McMahon, A.P. & Anderson, D.J. Transient expression of the bHLH factor neurogenin-2 marks a subpopulation of neural crest cells biased for a sensory but not a neuronal fate. Proc. Natl. Acad. Sci. USA 99, 8084–8089 (2002).
Blight, A.R. & Young, W. Central axons in injured cat spinal cord recover electrophysiological function following remyelination by Schwann cells. J. Neurol. Sci. 91, 15–34 (1989).
Gensert, J.M. & Goldman, J.E. Endogenous progenitors remyelinate demyelinated axons in the adult CNS. Neuron 19, 197–203 (1997).
Griffiths, I.R. & McCulloch, M.C. Nerve fibres in spinal cord impact injuries. Part 1. Changes in the myelin sheath during the initial 5 weeks. J. Neurol. Sci. 58, 335–349 (1983).
Nashmi, R. & Fehlings, M.G. Changes in axonal physiology and morphology after chronic compressive injury of the rat thoracic spinal cord. Neuroscience 104, 235–251 (2001).
Franklin, R.J., Gilson, J.M. & Blakemore, W.F. Local recruitment of remyelinating cells in the repair of demyelination in the central nervous system. J. Neurosci. Res. 50, 337–344 (1997).
Bambakidis, N.C. & Miller, R.H. Transplantation of oligodendrocyte precursors and sonic hedgehog results in improved function and white matter sparing in the spinal cords of adult rats after contusion. Spine J. 4, 16–26 (2004).
Utzschneider, D.A., Archer, D.R., Kocsis, J.D., Waxman, S.G. & Duncan, I.D. Transplantation of glial cells enhances action potential conduction of amyelinated spinal cord axons in the myelin-deficient rat. Proc. Natl. Acad. Sci. USA 91, 53–57 (1994).
Johansson, C.B. et al. Identification of a neural stem cell in the adult mammalian central nervous system. Cell 96, 25–34 (1999).
Falk, A. et al. Gene delivery to adult neural stem cells. Exp. Cell Res. 279, 34–39 (2002).
Bregman, B.S. et al. Recovery from spinal cord injury mediated by antibodies to neurite growth inhibitors. Nature 378, 498–501 (1995).
Basso, D.M., Beattie, M.S. & Bresnahan, J.C. A sensitive and reliable locomotor rating scale for open field testing in rats. J. Neurotrauma 12, 1–21 (1995).
Behrmann, D.L., Bresnahan, J.C., Beattie, M.S. & Shah, B.R. Spinal cord injury produced by consistent mechanical displacement of the cord in rats: behavioral and histologic analysis. J. Neurotrauma 9, 197–217 (1992).
Gale, K., Kerasidis, H. & Wrathall, J.R. Spinal cord contusion in the rat: behavioral analysis of functional neurologic impairment. Exp. Neurol. 88, 123–134 (1985).
Hargreaves, K., Dubner, R., Brown, F., Flores, C. & Joris, J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 32, 77–88 (1988).
Gundersen, H.J. Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. J. Microsc. 143, 3–45 (1986).
Mouton, P.R., Gokhale, A.M., Ward, N.L. & West, M.J. Stereological length estimation using spherical probes. J. Microsc. 206, 54–64 (2002).