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Pigment epithelium-derived growth factor: modulating adult neural stem cell self-renewal

Nature Neuroscience volume 12, pages 1481–1483 (2009)Cite this article

The vascular niche-derived factor PEDF enhances Notch signaling in adult neural stem cells via an unexpected mechanism involving nuclear export of a transcriptional repressor, to promote both proliferation and multipotentiality.

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Figure 1: PEDF's effects on adult periventricular NSC self-renewal.
Figure 2: An alternative interpretation of PEDF's role in regulating adult periventricular NSCs.

References

  1. Shen, Q. et al. Cell Stem Cell 3, 289–300 (2008).

    Article  CAS  Google Scholar 

  2. Tavazoie, M. et al. Cell Stem Cell 3, 279–288 (2008).

    Article  CAS  Google Scholar 

  3. Shen, Q. et al. Science 304, 1338–1340 (2004).

    Article  CAS  Google Scholar 

  4. Ramírez-Castillejo, C. et al. Nat. Neurosci. 9, 331–339 (2006).

    Article  Google Scholar 

  5. Nyfeler, Y. et al. EMBO J. 24, 3504–3515 (2005).

    Article  CAS  Google Scholar 

  6. Hitoshi, S. et al. Genes Dev. 16, 846–858 (2002).

    Article  CAS  Google Scholar 

  7. Andreu-Agulló, C., Morante-Redolat, J.M., Delgado, A.C. & Fariñas, I. Nat. Neurosci. 12, 1514–1523 (2009).

    Article  Google Scholar 

  8. Chojnacki, A.K., Mak, G.K. & Weiss, S. Nat. Rev. Neurosci. 10, 153–163 (2009).

    Article  CAS  Google Scholar 

  9. Reynolds, B.A. & Weiss, S. Science 255, 1707–1710 (1992).

    Article  CAS  Google Scholar 

  10. Hermanson, O., Jepsen, K. & Rosenfeld, M.G. Nature 419, 934–939 (2002).

    Article  CAS  Google Scholar 

  11. Notari, L. et al. J. Biol. Chem. 281, 38022–38037 (2006).

    Article  CAS  Google Scholar 

  12. Doetsch, F., Petreanu, L., Caille, I., Garcia-Verdugo, J.M. & Alvarez-Buylla, A. Neuron 36, 1021–1034 (2002).

    Article  CAS  Google Scholar 

  13. Givogri, M.I. et al. Dev. Neurosci. 28, 81–91 (2006).

    Article  CAS  Google Scholar 

  14. Burrows, R.C., Wancio, D., Levitt, P. & Lillien, L. Neuron 19, 251–267 (1997).

    Article  CAS  Google Scholar 

  15. Qu, Q. & Shi, Y. J. Cell. Physiol. 221, 5–9 (2009).

    Article  CAS  Google Scholar 

Download references

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  1. Department of Cell Biology and Anatomy, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada

    Andrew Chojnacki & Samuel Weiss

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  1. Andrew Chojnacki
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  2. Samuel Weiss
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Correspondence to Andrew Chojnacki or Samuel Weiss.

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Chojnacki, A., Weiss, S. Pigment epithelium-derived growth factor: modulating adult neural stem cell self-renewal. Nat Neurosci 12, 1481–1483 (2009). https://doi.org/10.1038/nn1209-1481

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