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Gephyrin, a major player in GABAergic postsynaptic membrane assembly?

Nature Neuroscience volume 1, pages 541–543 (1998)Cite this article

Abstract

A new study shows that the glycine receptor clustering protein gephyrin is involved in postsynaptic localization of GABAA receptors, which also requires the receptor's γ2 subunit.

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Figure 1: Mechanisms proposed to cause a loss of GABAA receptor clusters in γ2-deficient mice.

References

  1. Günther, U. et al. Proc. Natl. Acad. Sci. USA 92, 7749 –7753 (1995).

    Article  Google Scholar 

  2. Prior, P. et al. Neuron 8, 1161–1170 (1992).

    Article  CAS  Google Scholar 

  3. Kirsch, J., Wolters, I., Triller, A. & Betz, H. Nature 366, 745–748 (1993).

    Article  CAS  Google Scholar 

  4. Sassoè-Pognetto, M. et al. J. Comp. Neurol. 357, 1– 14 (1995).

    Article  Google Scholar 

  5. Craig, A. M., Banker, G., Chang, W., McGrath, M. E. & Serpinskaya, A. S. J. Neurosci. 16, 3166– 3177 (1996).

    Article  CAS  Google Scholar 

  6. Kirsch, J. & Betz, H. J. Neurosci. 15, 4148–4156 (1995).

    Article  CAS  Google Scholar 

  7. Triller, A., Cluzeaud, F. & Korn, H. J. Cell Biol. 104, 947– 956 (1987).

    Article  CAS  Google Scholar 

  8. Todd, A. J., Spike, R. C., Chong, D. & Neilson, M. Eur. J. Neurosci. 7, 1–11 (1995 ).

    Article  CAS  Google Scholar 

  9. Kirsch, J. & Betz, H. Nature 392, 717–720 (1998).

    Article  CAS  Google Scholar 

  10. Levi, S., Vannier, C. & Triller, A. J. Cell Sci. 111, 335– 345 (1998).

    CAS  PubMed  Google Scholar 

  11. Meyer, G., Kirsch, J., Betz, H. & Langosch, D. Neuron 15, 563–572 (1995).

    Article  CAS  Google Scholar 

  12. Kirsch, J., Kuhse, J. & Betz, H. Mol. Cell. Neurosci. 6, 450–461 (1995).

    Article  CAS  Google Scholar 

  13. Triller, A., Seitanidou, T., Franksson, O. & Korn, H. New Biologist 2, 637–641 (1990).

    CAS  PubMed  Google Scholar 

  14. Snyder, S. H., Lai, M. M. & Burnett, P. E. Neuron 21, 283– 294 (1998).

    Article  CAS  Google Scholar 

  15. Stallmeyer, B., Nerlich, A., Schiemann, J., Brinkmann, H. & Mendel, R. R. Plant J. 8, 751–762 (1995).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Max-Plank-Institute for Brain Research, Deparment of Neurochemistry, Deutschordenstrasse 46, Frankfurt, 60528, Germany

    Heinrich Betz

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  1. Heinrich Betz
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Betz, H. Gephyrin, a major player in GABAergic postsynaptic membrane assembly? . Nat Neurosci 1, 541–543 (1998). https://doi.org/10.1038/2777

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