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Food for thought: a receptor finds its ligand

In C. elegans, social and solitary feeding behavior can be determined by a single amino acid change in a G protein–coupled receptor. A new study identifies ligands for this receptor and suggests how changes in behavior evolve at the molecular level.

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Figure 1: Differential responses of NPR-1 215F and NPR-1 215V receptors to ligand result in changes in feeding behavior.

References

  1. White, J.G., Southgate, E., Thomson, J.N. & Brenner, S. Philos. Trans. R. Soc. Lond. B Biol. Sci. 314, 1–340 (1986).

    Article  CAS  Google Scholar 

  2. de Bono, M. & Bargmann, C.I. Cell 94, 679–689 (1998).

    Article  CAS  Google Scholar 

  3. de Bono, M., Tobin, D.M., Davis, M.W., Avery, L. & Bargmann, C.I. Nature 419, 899–903 (2002).

    Article  CAS  Google Scholar 

  4. Coates, J.C. & de Bono, M. Nature 419, 925–929 (2002).

    Article  CAS  Google Scholar 

  5. Rogers, C. et al. Nat. Neurosci. 6, 1178–1185 (2003).

    Article  CAS  Google Scholar 

  6. Li, C., Nelson, L.S., Kim, K., Nathoo, A. & Hart, A.C. Ann. NY Acad. Sci. 897, 239–252 (1999).

    Article  CAS  Google Scholar 

  7. Li, C., Kim, K. & Nelson, L.S. Brain Res. 848, 26–34 (1999).

    Article  CAS  Google Scholar 

  8. Kubiak, T.M. et al. J. Biol. Chem. 278, 33724–33729 (2003).

    Article  CAS  Google Scholar 

  9. Kubiak, T.M. et al. J. Biol. Chem. doi:10.1074/jbc.M304056200 (2003).

Download references

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Potter, C., Luo, L. Food for thought: a receptor finds its ligand. Nat Neurosci 6, 1119–1120 (2003). https://doi.org/10.1038/nn1103-1119

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