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Axon guidance mechanisms: semaphorins as simultaneous repellents and anti-repellents

Abstract

Semaphorins A and E are known to potently repel sympathetic axons. New work indicates that they can also antagonize the repellent action of semaphorin D at sensory axons.

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Figure 1: Structures of semaphorins and neuropilins.
Figure 2: Specificity of action of different class III semaphorins.

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Chen, H., He, Z. & Tessier-Lavigne, M. Axon guidance mechanisms: semaphorins as simultaneous repellents and anti-repellents. Nat Neurosci 1, 436–439 (1998). https://doi.org/10.1038/2154

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