The diffusible signal Sonic Hedgehog (Shh) controls cell type specification in the ventral spinal cord. Litingtung and Chiang now show that some defects due to the lack of Shh are rescued by deleting the transcription factor Gli3, suggesting that Shh works by inactivating Gli3.
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Stone, D., Rosenthal, A. Achieving neuronal patterning by repression. Nat Neurosci 3, 967–969 (2000). https://doi.org/10.1038/79894
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DOI: https://doi.org/10.1038/79894
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