Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Regenerating nerves follow the road more traveled

An in-vivo imaging study shows that regenerating axons retrace their previous paths after nerve crush, apparently guided by the mechanical properties of endoneurial tubes.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: During outgrowth to their targets, developing axons respond to a number of attractive and repulsive chemical and matrix-bound cues, as well as activity-dependent factors.

Ivelisse Robles

References

  1. Tessier-Lavigne, M. & Goodman, C.S. Science 274, 1123–1133 (1996).

    CAS  Google Scholar 

  2. Yu, T.W. & Bargmann, C.I. Nat. Neurosci. 4, 1169–1176 (2001).

    Article  CAS  Google Scholar 

  3. Nguyen, Q.T., Sanes, J.R. & Lichtman, J.W. Nat. Neurosci. 5, 861–867 (2002).

    Article  CAS  Google Scholar 

  4. Bonilla, I.E., Tanabe, K. & Strittmatter, S.M. J. Neurosci. 22, 1303–1315 (2002).

    Article  CAS  Google Scholar 

  5. Cajal, R. Degeneration and Regeneration of the Nervous System Vol. 1 (eds. DeFelipe, J. & Jones, E. G.) 66–304 (Oxford Univ. Press, New York, 1991).

    Google Scholar 

  6. Heidemann, S.R., Lamoureux, P. & Buxbaum, R.E. J. Cell Biol. 111, 1949–1957 (1990).

    Article  CAS  Google Scholar 

  7. GrandPre, T., Nakamura, F., Vartanian, T. & Strittmatter, S.M. Nature 403, 439–444 (2000).

    Article  CAS  Google Scholar 

  8. GrandPre, T., Li, S. & Strittmatter, S.M. Nature 417, 547–551 (2002).

    Article  CAS  Google Scholar 

  9. Huber, A.B. & Schwab, M.E. Biol. Chem. 381, 407–419 (2000).

    Article  CAS  Google Scholar 

  10. Prinjha, R. et al. Nature 403, 383–384 (2000).

    Article  CAS  Google Scholar 

  11. Wang, X. et al. J. Neurosci. 22, 5505–5515 (2002).

    Article  CAS  Google Scholar 

  12. Bradbury, E.J. et al. Nature 416, 636–640 (2002).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fournier, A., Strittmatter, S. Regenerating nerves follow the road more traveled. Nat Neurosci 5, 821–822 (2002). https://doi.org/10.1038/nn0902-821

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn0902-821

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing