Melanocortin signaling in the CNS, which crucially regulates feeding and energy expenditure, also regulates the expression of a hepatic cholesterol re-uptake receptor. Thus, the brain in rodents directly controls the levels of circulating high-density cholesterol species. The relevance to human cholesterol metabolism remains unknown.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Lund-Katz, S. & Phillips, M.C. Subcell. Biochem. 51, 183–227 (2010).
Perez-Tilve, D. et al. Nat. Neurosci. 13, 877–882 (2010).
Oswal, A. & Yeo, G.S. Obes. Rev. 8, 293–306 (2007).
Farooqi, I.S. et al. J. Clin. Invest. 106, 271–279 (2000).
Coll, A.P., Farooqi, I.S. & O'Rahilly, S. Cell 129, 251–262 (2007).
Nakazato, M. et al. Nature 409, 194–198 (2001).
Ma, X., Bruning, J. & Ashcroft, F.M. J. Neurosci. 27, 7125–7129 (2007).
Acton, S. et al. Science 271, 518–520 (1996).
Lambert, G. et al. J. Biol. Chem. 278, 2563–2570 (2003).
Schoonjans, K. et al. EMBO Rep. 3, 1181–1187 (2002).
Ollmann, M.M. et al. Science 278, 135–138 (1997).
Balthasar, N. et al. Cell 123, 493–505 (2005).
Greenfield, J.R. et al. N. Engl. J. Med. 360, 44–52 (2009).
Wikberg, J.E. & Mutulis, F. Nat. Rev. Drug Discov. 7, 307–323 (2008).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Tung, YC., Yeo, G. Central melanocortin signaling regulates cholesterol. Nat Neurosci 13, 779–780 (2010). https://doi.org/10.1038/nn0710-779
Issue Date:
DOI: https://doi.org/10.1038/nn0710-779
