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Something old, something new: BDNF-induced neuron survival requires TRPC channel function

Transient receptor potential (TRP) channels participate in many diverse neuronal functions. A study in this issue now shows that TRPC-dependent calcium fluxes are also crucial to neurotrophin-induced cell survival signaling.

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Figure 1: BDNF-induced and activity-dependent survival mechanisms rely on convergent Ca2+-dependent signaling pathways.

Katie Ris

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Sossin, W., Barker, P. Something old, something new: BDNF-induced neuron survival requires TRPC channel function. Nat Neurosci 10, 537–538 (2007). https://doi.org/10.1038/nn0507-537

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