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Presynaptic NMDA receptors get into the act

Nature Neuroscience volume 7, pages 419–420 (2004)Cite this article

In a new form of synaptic plasticity, depolarization of Purkinje cells increases the frequency of mini GABAergic IPSCs, via glutamate acting as a retrograde messenger on presynaptic NMDA receptors on the terminals of cerebellar interneurons.

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Figure 1: Three forms of calcium-induced plasticity at inhibitory interneuron–Purkinje cell synapses.

Debbie Maizels

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  1. Departments of Cellular and Molecular Pharmacology and Physiology, University of California at San Francisco, San Francisco, 94943, California, USA

    Anastassios V Tzingounis & Roger A Nicoll

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  1. Anastassios V Tzingounis
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  2. Roger A Nicoll
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Tzingounis, A., Nicoll, R. Presynaptic NMDA receptors get into the act. Nat Neurosci 7, 419–420 (2004). https://doi.org/10.1038/nn0504-419

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