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Axon growth inhibition: signals from the p75 neurotrophin receptor

Axon growth after CNS injury is restricted in part by several inhibitors found in myelin. The inhibition requires interaction of the Nogo receptor with the p75 neurotrophin receptor. A new paper now shows that the Rho inhibitor Rho-GDIα mediates this signaling.

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Figure 1: Mechanisms of axonal growth inhibition by the p75 neurotrophin receptor (p75NTR) and growth inhibitory molecules (MAG/Nogo).

Erin Boyle

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Kaplan, D., Miller, F. Axon growth inhibition: signals from the p75 neurotrophin receptor. Nat Neurosci 6, 435–436 (2003). https://doi.org/10.1038/nn0503-435

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