Axon growth after CNS injury is restricted in part by several inhibitors found in myelin. The inhibition requires interaction of the Nogo receptor with the p75 neurotrophin receptor. A new paper now shows that the Rho inhibitor Rho-GDIα mediates this signaling.
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References
Yamashita, T. & Tohyama, M. Nat. Neurosci. 6, 461–467 (2003).
McKerracher, L. & Winton, M.J. Neuron 36, 345–348 (2002).
Woolf, C.J. & Bloechlinger, S. Science 297, 1132–1134 (2002).
Yamashita, T., Higuchi, H. & Tohyama, M. J. Cell Biol. 157, 565–570 (2002).
Wong, S.T. et al. Nat. Neurosci. 5, 1302–1308 (2002).
Wang, K.C., Kim, J.A., Sivasankaran, R., Segal, R. & He, Z. Nature 420, 74–78 (2002).
Etienne-Manneville, S. & Hall, A. Nature 420, 629–635 (2002).
Olofsson, B. Cell. Signal. 11, 545–554 (1999).
Hoffman, G.R., Nassar, N. & Cerione, R.A. Cell 100, 345–356 (2000).
Del Pozo, M.A. et al. Nat. Cell Biol. 3, 232–239 (2002).
GrandPre, T., Li, S. & Strittmatter, S.M. Nature 417, 547–551 (2002).
Boyd, J.G. & Gordon, T. Eur. J. Neurosci. 15, 613–626 (2002).
Hempstead, B.L. Curr. Opin. Neurobiol. 12, 260–267 (2002).
Kohn, J., Aloyz, R.S., Toma, J.G., Haak-Frendscho, M. & Miller, F.D. J. Neurosci. 19, 5393–5408 (1999).
Walsh, G.S., Krol, K.M., Crutcher, K.A. & Kawaja, M.D. J. Neurosci. 19, 4155–4168 (1999).
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Kaplan, D., Miller, F. Axon growth inhibition: signals from the p75 neurotrophin receptor. Nat Neurosci 6, 435–436 (2003). https://doi.org/10.1038/nn0503-435
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DOI: https://doi.org/10.1038/nn0503-435
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