Abstract
The neuropeptide αCGRP (calcitonin gene-related peptide) is involved in the complex process of pain signaling, but the precise contribution of αCGRP remains unclear. Here we show that mice lacking αCGRP display an attenuated response to chemical pain and inflammation. Furthermore, αCGRP−/− mice do not show changes in heroin self-administration or morphine tolerance, but display a marked decrease in morphine withdrawal signs, suggesting an important contribution of αCGRP to opiate withdrawal.
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Acknowledgements
This work was supported by grants from the Collège de France, the Association Française Contre les Myopathies, the Ligue Nationale Contre le Cancer, EEC Biomed and Biotech Programs BMHICT-941060 and 960236, NIH DA-05274, the National Association for Research on Schizophrenia and Depression, and Glaxo Wellcome.
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Salmon, AM., Damaj, M., Marubio, L. et al. Altered neuroadaptation in opiate dependence and neurogenic inflammatory nociception in αCGRP-deficient mice. Nat Neurosci 4, 357–358 (2001). https://doi.org/10.1038/86001
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DOI: https://doi.org/10.1038/86001
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