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Synuclein and dopamine: the Bonnie and Clyde of Parkinson's disease

Nature Neuroscience volume 20, pages 1514–1515 (2017)Cite this article

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An Author Correction to this article was published on 20 December 2017

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Mouse models have generally failed to recapitulate the dopaminergic neurodegeneration seen in Parkinson's disease. Expressing mutant α-synuclein in a background of elevated dopamine generates mice with nigrostriatal degeneration.

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Figure 1: Schematic of a dopaminergic neuron with striatal synaptic terminals.

Change history

  • 20 December 2017

    In the version of this article initially published, the molecular mass of synuclein was given as 140 kDa instead of ∼14 kDa. The error has been corrected in the HTML and PDF versions of the article.

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  1. the University of Wisconsin-Madison, Wisconsin Institute for Medical Research, Madison, Wisconsin, USA

    Subhojit Roy

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Roy, S. Synuclein and dopamine: the Bonnie and Clyde of Parkinson's disease. Nat Neurosci 20, 1514–1515 (2017). https://doi.org/10.1038/nn.4660

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