A previously unknown mechanism contributes to dysfunction of the neurogenic niche during CNS autoimmunity. Natural killer cells are retained specifically in the subventricular zone in chronic disease, killing stem cells and promoting pathology.
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References
Rasmussen, S. et al. Ann. Neurol. 69, 878–891 (2011).
Liu, Q. et al. Nat. Neurosci. 19, Shi nn.4211 (2016).
Kadri, N., Thanh, T.L. & Höglund, P. Immunol. Rev. 267, 167–177 (2015).
Morandi, B. et al. Pharmacol. Res. 57, 1–5 (2008).
Chanvillard, C., Jacolik, R.F., Infante-Duarte, C. & Nayak, R.C. Front. Immunol. 4, 63 (2013).
Kastrukoff, L.F. et al. J. Neuroimmunol. 145, 103–114 (2003).
Xu, J., Vallejo, A.N., Jiang, Y., Weyand, C.M. & Goronzy, J.J. J. Biol. Chem. 280, 24277–24285 (2005).
Hammarberg, H. et al. J. Neurosci. 20, 5283–5291 (2000).
Ranson, T. et al. Blood 101, 4887–4893 (2003).
Gómez-Nicola, D., Valle-Argos, B., Pallas-Bazarra, N. & Nieto-Sampedro, M. Mol. Biol. Cell 22, 1960–1970 (2011).
Pluchino, S. et al. Brain 131, 2564–2578 (2008).
Shatz, C.J. Neuron 64, 40–45 (2009).
Wheeler, M.A. et al. Neuron 82, 587–602 (2014).
Stevens, B. et al. Cell 131, 1164–1178 (2007).
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Gadani, S., Kipnis, J. Natural killers in the brain's nursery. Nat Neurosci 19, 176–177 (2016). https://doi.org/10.1038/nn.4227
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DOI: https://doi.org/10.1038/nn.4227