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Does the hippocampus preplay memories?

Previous studies have reported 'preplay' of hippocampal neural activity patterns associated with events yet to occur. Silva et al. challenge this finding on the basis of large-scale recordings before and after experiences.

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Figure 1: Models of memory-related sequence generation in neural hippocampal activity.

Marina Corral Spence/Nature Publishing Group

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Correspondence to Howard Eichenbaum.

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Eichenbaum, H. Does the hippocampus preplay memories?. Nat Neurosci 18, 1701–1702 (2015). https://doi.org/10.1038/nn.4180

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