Abstract

We investigated the relationship between individual subjects' functional connectomes and 280 behavioral and demographic measures in a single holistic multivariate analysis relating imaging to non-imaging data from 461 subjects in the Human Connectome Project. We identified one strong mode of population co-variation: subjects were predominantly spread along a single 'positive-negative' axis linking lifestyle, demographic and psychometric measures to each other and to a specific pattern of brain connectivity.

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Acknowledgements

We thank our many colleagues in the WU-Minn HCP Consortium for their invaluable contributions in generating the publicly available HCP data and implementing the procedures needed to acquire, analyze, visualize and share these data sets. We are grateful for funding from the US National Institutes of Health (grants 1U54MH091657, P30-NS057091, P41-RR08079/EB015894 and F30-MH097312) and the Wellcome Trust (grants 098369/Z/12/Z and 091509/Z/10/Z).

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Affiliations

  1. Oxford University Centre for Functional MRI of the Brain (FMRIB), Oxford, UK.

    • Stephen M Smith
    • , Anderson M Winkler
    • , Timothy E J Behrens
    •  & Karla L Miller
  2. Department of Statistics and Warwick Manufacturing Group, University of Warwick, Coventry, UK.

    • Thomas E Nichols
  3. Oxford University Centre for Human Brain Activity (OHBA), Oxford, UK.

    • Diego Vidaurre
  4. Washington University School of Medicine, Washington University, St. Louis, Missouri, USA.

    • Matthew F Glasser
    • , Deanna M Barch
    •  & David C Van Essen
  5. Center for Magnetic Resonance Research, University of Minnesota, Minnesota, USA.

    • Kamil Ugurbil

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Contributions

D.V.E., K.U., D.B., T.B., M.G. and S.S. contributed to the data acquisition and image processing. S.S., K.M., T.N., D.V., A.W. and T.B. designed and carried out the statistical analyses. All of the authors contributed to writing the paper.

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Stephen M Smith.

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DOI

https://doi.org/10.1038/nn.4125