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Unlocking the constraints on memory formation

A leading therapeutic molecule for multiple sclerosis, FTY720, is shown to mimic a key component of sphingolipid signaling, resulting in specific manipulation of histone deacetylases and the extinction of memory.

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Figure 1: A nuclear role for FTY720-P.

References

  1. Hait, N.C. et al. Science 325, 1254–1257 (2009).

    Article  CAS  Google Scholar 

  2. Hait, N.C. et al. Nat. Neurosci. 17, 971–980 (2014).

    Article  CAS  Google Scholar 

  3. Brinkmann, V. et al. Nat. Rev. Drug Discov. 9, 883–897 (2010).

    Article  CAS  Google Scholar 

  4. Brinkmann, V. et al. J. Biol. Chem. 277, 21453–21457 (2002).

    Article  CAS  Google Scholar 

  5. Zemann, B. et al. Blood 15, 1454–1458 (2006).

    Article  Google Scholar 

  6. McQuown, S.C. et al. J. Neurosci. 31, 764–774 (2011).

    Article  CAS  Google Scholar 

  7. Peixoto, L. & Abel, T. Neuropsychopharmacology 38, 62–76 (2013).

    Article  CAS  Google Scholar 

  8. Day, J.J. & Sweatt, J.D. Neuron 70, 813–829 (2011).

    Article  CAS  Google Scholar 

  9. Lattal, K.M. & Wood, M.A. Nat. Neurosci. 16, 124–129 (2013).

    Article  CAS  Google Scholar 

  10. Lattal, K.M., Barrett, R.M. & Wood, M.A. Behav. Neurosci. 121, 1125–1131 (2007).

    Article  CAS  Google Scholar 

  11. Bredy, T.W. et al. Learn. Mem. 14, 268–276 (2007).

    Article  CAS  Google Scholar 

  12. Malvaez, M. et al. Proc. Natl. Acad. Sci. USA 110, 2647–2652 (2013).

    Article  CAS  Google Scholar 

  13. Morris, M.J. et al. J. Neurosci. 33, 6401–6411.

  14. Bahari-Javan, S. et al. J. Neurosci. 32, 5062–5073 (2012).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Dina P Matheos or Marcelo A Wood.

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Matheos, D., Wood, M. Unlocking the constraints on memory formation. Nat Neurosci 17, 895–896 (2014). https://doi.org/10.1038/nn.3748

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