Brief Communication | Published:

Post-study caffeine administration enhances memory consolidation in humans

Nature Neuroscience volume 17, pages 201203 (2014) | Download Citation

  • A Corrigendum to this article was published on 26 August 2014

Abstract

It is currently not known whether caffeine has an enhancing effect on long-term memory in humans. We used post-study caffeine administration to test its effect on memory consolidation using a behavioral discrimination task. Caffeine enhanced performance 24 h after administration according to an inverted U-shaped dose-response curve; this effect was specific to consolidation and not retrieval. We conclude that caffeine enhanced consolidation of long-term memories in humans.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from $8.99

All prices are NET prices.

Change history

  • Corrected online 17 January 2014

    In the version of this article initially published, in the first sentence in the Online Methods, the s.d. of the age of the subjects was missing and the number of female subjects was given as 280. The s.d. is 2 years and the number of female subjects is 80. The error has been corrected in the HTML and PDF versions of the article.

  • Corrected online 30 October 2014

    In the version of this article initially published, there were errors in the reporting of statistics. In the Figure 1b legend, the asterisked P value was given in the HTML version as *P = 0.05 and in the PDF version as *P < 0.05. It should read *P < 0.05, one-tailed. In the Figure 2a legend, the degrees of freedom for the immediate caffeine group were given as 42 and the P value as 0.05; the correct values are 71 and 0.049, respectively. In the Figure 2b legend and the fifth paragraph of the main text, the P value for the main effect of caffeine was given as 0.001; the correct value is 0.05. The errors have been corrected in the HTML and PDF versions of the article.

References

  1. 1.

    J. Alzheimers Dis. 20 (suppl. 1) S85–S94 (2010).

  2. 2.

    Science 287, 248–251 (2000).

  3. 3.

    & Trends Neurosci. 34, 515–525 (2011).

  4. 4.

    et al. Hippocampus 21, 968–979 (2011).

  5. 5.

    & J. Alzheimers Dis. 20 (suppl. 1) S95–S116 (2010).

  6. 6.

    et al. Neuroscience 142, 941–952 (2006).

  7. 7.

    et al. Neuropharmacology 64, 153–159 (2013).

  8. 8.

    , , , & Neuroscience 153, 1071–1078 (2008).

  9. 9.

    , , & Psychopharmacology (Berl.) 146, 214–219 (1999).

  10. 10.

    et al. Science 339, 1202–1204 (2013).

  11. 11.

    , , , & Neurobiol. Learn. Mem. 97, 465–469 (2012).

  12. 12.

    et al. Neuroscience 93, 955–967 (1999).

  13. 13.

    , , & Nat. Neurosci 15, 23–25 (2012).

  14. 14.

    , & Learn. Mem. 19, 391–400 (2012).

  15. 15.

    , , & J. Neurosci. 29, 8206–8214 (2009).

  16. 16.

    et al. Science 333, 891–895 (2011).

  17. 17.

    Annu. Rev. Neurosci. 27, 1–28 (2004).

  18. 18.

    , , , & Proc. Natl. Acad. Sci. USA 110, 3597–3602 (2013).

  19. 19.

    & Trends Cogn. Sci. 14, 464–472 (2010).

  20. 20.

    & Psychol. Rep. 89, 521–526 (2001).

  21. 21.

    & Mem. Syst. 1994, 87–117 (1994).

  22. 22.

    , & Psychol. Rev. 102, 419–457 (1995).

  23. 23.

    & Trends Cogn. Sci. 6, 505–510 (2002).

  24. 24.

    , & Biomed. Chromatogr. 24, 1136–1144 (2010).

Download references

Acknowledgements

M.A.Y. is supported by US National Institute on Aging P50 AG05146 and R01 AG034613. J.P.T. is supported by US National Science Foundation CHE-1213438. D.B. is supported by a Johns Hopkins University Provost Undergraduate Research Award. We thank A. Newman and C. Townsend for the use of their high-performance liquid chromatography instrument, D. Spira, A. Ward and J. Kim for help with participant testing, Z. Reagh for help with data analysis, and J. Knierim for helpful discussions regarding this manuscript.

Author information

Affiliations

  1. Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland, USA.

    • Daniel Borota
    • , Elizabeth Murray
    • , Allen Chang
    • , Joseph M Watabe
    • , Maria Ly
    •  & Michael A Yassa
  2. Department of Chemistry, Johns Hopkins University, Baltimore, Maryland, USA.

    • Gizem Keceli
    •  & John P Toscano
  3. Department of Neurobiology and Behavior, University of California, Irvine, California, USA.

    • Michael A Yassa

Authors

  1. Search for Daniel Borota in:

  2. Search for Elizabeth Murray in:

  3. Search for Gizem Keceli in:

  4. Search for Allen Chang in:

  5. Search for Joseph M Watabe in:

  6. Search for Maria Ly in:

  7. Search for John P Toscano in:

  8. Search for Michael A Yassa in:

Contributions

D.B., J.P.T. and M.A.Y. designed the study. D.B., E.M., G.K., A.C., J.M.W. and M.L. conducted the experiments. D.B. and M.A.Y. wrote the manuscript with input from all authors.

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Michael A Yassa.

Integrated supplementary information

Supplementary information

PDF files

  1. 1.

    Supplementary Text and Figures

    Supplementary Figures 1–2 and Supplementary Table 1

About this article

Publication history

Received

Accepted

Published

DOI

https://doi.org/10.1038/nn.3623