Genome-wide approaches are used to discover the RNA-binding targets of the amyotrophic lateral sclerosis (ALS) disease protein FUS/TLS. These studies reveal some shared targets with another ALS-linked RNA-binding protein, TDP-43, suggesting common pathogenic mechanisms.
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References
Lagier-Tourenne, C., Polymenidou, M. & Cleveland, D.W. Hum. Mol. Genet. 19, R46–R64 (2010).
Lagier-Tourenne, C. Nat. Neurosci. 15, 1488–1497 (2012).
Polymenidou, M. et al. Nat. Neurosci. 14, 459–468 (2011).
Tollervey, J.R. et al. Nat. Neurosci. 14, 452–458 (2011).
Sephton, C.F. et al. J. Biol. Chem. 286, 1204–1215 (2011).
Xiao, S. et al. Mol. Cell. Neurosci. 47, 167–180 (2011).
Colombrita, C. et al. J. Biol. Chem. 287, 15635–15647 (2012).
Hoell, J.I. et al. Nat. Struct. Mol. Biol. 18, 1428–1431 (2011).
Rogelj, B. et al. Sci. Rep. 2, 603 (2012).
Ishigaki, S. et al. Sci. Rep. 2, 529 (2012).
Couthouis, J. et al. Proc. Natl. Acad. Sci. USA 108, 20881–20890 (2011).
King, O.D., Gitler, A.D. & Shorter, J. Brain Res. 1462, 61–80 (2012).
Neumann, M. et al. Brain 134, 2595–2609 (2011).
DeJesus-Hernandez, M. et al. Neuron 72, 245–256 (2011).
Renton, A.E. et al. Neuron 72, 257–268 (2011).
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Gitler, A. TDP-43 and FUS/TLS yield a target-rich haul in ALS. Nat Neurosci 15, 1467–1469 (2012). https://doi.org/10.1038/nn.3243
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DOI: https://doi.org/10.1038/nn.3243
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