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Navigating uncertain waters

Mice lacking NMDA receptors in the dentate gyrus and CA1 subfields of the hippocampus form spatial memories just as well as wild-type mice, but they disregard them when confounded by ambiguous local cues. Hippocampal NMDA receptors may influence spatial memory more subtly than previously thought.

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Figure 1: Ambiguous cues disrupt water maze performance in CA1 and dentate gyrus NMDA receptor knockout mice.

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Correspondence to Mark Mayford.

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Mayford, M. Navigating uncertain waters. Nat Neurosci 15, 1056–1057 (2012). https://doi.org/10.1038/nn.3174

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