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Microglia and monocytes: 'tis plain the twain meet in the brain

In a model of multiple sclerosis, tracing the fates of peripheral myeloid cells versus microglia fingers the peripheral cells in paralysis onset. Despite vigorous accumulation, peripheral cells disappear after disease resolution.

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Figure 1: Monocytes and microglia in parallel universes.

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Correspondence to Richard M Ransohoff.

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Ransohoff, R. Microglia and monocytes: 'tis plain the twain meet in the brain. Nat Neurosci 14, 1098–1100 (2011). https://doi.org/10.1038/nn.2917

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