A new study used several mouse mutants to study insulin receptor function specifically in the ventromedial nucleus of the hypothalamus (VMH), and found a role for VMH insulin signaling in promoting high-fat diet–induced obesity.
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Yi, CX., Scherer, T. & Tschöp, M. Cajal revisited: does the VMH make us fat?. Nat Neurosci 14, 806–808 (2011). https://doi.org/10.1038/nn.2867
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DOI: https://doi.org/10.1038/nn.2867