A study now shows that association of kainate receptors with the auxiliary protein Neto1 confers the slow activation and deactivation kinetics of synaptic responses, as well as the high agonist affinity seen in vivo.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Straub, C. et al. Nat. Neurosci. 14, 866–873 (2011).
Nicoll, R.A., Tomita, S. & Bredt, D.S. Science 311, 1253–1256 (2006).
Zhang, W. et al. Neuron 61, 385–396 (2009).
Ng, D. et al. PLoS Biol. 7, e41 (2009).
Lerma, J. Neuron 19, 1155–1158 (1997).
Castillo, P.E., Malenka, R.C. & Nicoll, R.A. Nature 388, 182–186 (1997).
Copits, B.A., Robbins, J.S., Frauto, S. & Swanson, G.T. J. Neurosci. 31, 7334–7340 (2011).
Sachidhanandam, S., Blanchet, C., Jeantet, Y., Cho, Y.H. & Mulle, C. J. Neurosci. 29, 5000–5008 (2009).
Nakashiba, T., Young, J.Z., McHugh, T.J., Buhl, D.L. & Tonegawa, S . Science 319, 1260–1264 (2008).
Lerma, J. Nat. Rev. Neurosci. 4, 481–495 (2003).
Zheng, Y., Mellem, J.E., Brockie, P.J., Madsen, D.M. & Maricq, A.V. Nature 427, 451–457 (2004).
Gally, C., Eimer, S., Richmond, J.E. & Bessereau, J.L. Nature 431, 578–582 (2004).
Weston, M.C., Schuck, P., Ghosal, A., Rosenmund, C. & Mayer, M.L. Nat. Struct. Mol. Biol. 13, 1120–1127 (2006).
Vincent, P. & Mulle, C. Neuroscience 158, 309–323 (2009).
Monaghan, D.T. & Cotman, C.W. Brain Res. 252, 91–100 (1982).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Lerma, J. Net(o) excitement for kainate receptors. Nat Neurosci 14, 808–810 (2011). https://doi.org/10.1038/nn.2864
Published:
Issue Date:
DOI: https://doi.org/10.1038/nn.2864
