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TDP-43: multiple targets, multiple disease mechanisms?

Nature Neuroscience volume 14, pages 403–405 (2011)Cite this article

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Cytoplasmic inclusions containing TDP-43 are a hallmark of certain neurodegenerative diseases. Two new reports demonstrate that this protein binds a broad range of RNA transcripts, with a preference for UG-rich intronic regions.

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Figure 1: UV cross-linking of TDP-43 to RNA, subsequent immunoprecipitation and sequencing reveals many targets in introns, but also in noncoding RNAs and 3′ UTRs of mRNAs.

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  1. Michael Sendtner is at the Institute for Clinical Neurobiology, University of Wuerzburg, Germany.,

    Michael Sendtner

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  1. Michael Sendtner
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Correspondence to Michael Sendtner.

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Sendtner, M. TDP-43: multiple targets, multiple disease mechanisms?. Nat Neurosci 14, 403–405 (2011). https://doi.org/10.1038/nn.2784

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