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Selective suppression of hippocampal ripples impairs spatial memory

Nature Neuroscience volume 12, pages 12221223 (2009) | Download Citation

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Abstract

Sharp wave–ripple (SPW-R) complexes in the hippocampus-entorhinal cortex are believed to be important for transferring labile memories from the hippocampus to the neocortex for long-term storage. We found that selective elimination of SPW-Rs during post-training consolidation periods resulted in performance impairment in rats trained on a hippocampus-dependent spatial memory task. Our results provide evidence for a prominent role of hippocampal SPW-Rs in memory consolidation.

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Change history

  • 20 September 2009

    In the version of this supplementary file originally posted online, part of Supplementary Figure 3 was missing. The error has been corrected in this file as of 20 September 2009. In addition, Gabrielle Girardeau was incorrectly listed as a corresponding author in the HTML version that was originally posted online. The correct corresponding author is György Buzsáki. The error has been corrected in the HTML version of the article.

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Acknowledgements

We thank S. Sara, A. Larrieu, L. Hazan, A. Fruchart, P. Ruther, S. Kisban, S. Herwik, S. Doutremer, M.-A. Thomas, Y. Dupraz, M. Ehrette and S. Rateau for advice and technical support. This work was supported by the International Human Frontiers Science Program Organization (CDA0061/2007-C), the US National Institutes of Health (NS34994), European Projects NeuroProbes (IST-027017) and Integrating Cognition, Emotion and Autonomy (FP6-IST 027819), and a Collège de France Visiting Professor Fellowship.

Author information

Author notes

    • Gabrielle Girardeau
    •  & Karim Benchenane

    These authors contributed equally to this work.

Affiliations

  1. Laboratoire de Physiologie de la Perception et de l'Action, Collège de France, CNRS, Paris, France.

    • Gabrielle Girardeau
    • , Karim Benchenane
    • , Sidney I Wiener
    •  & Michaël B Zugaro
  2. Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, New Jersey, USA.

    • György Buzsáki

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Contributions

G.B. and M.B.Z. designed the study. G.G. carried out the majority of the experiments, K.B. and M.B.Z. carried out the remaining experiments. M.B.Z., G.G. and K.B. analyzed the data. All of the authors contributed to writing the manuscript.

Corresponding authors

Correspondence to György Buzsáki or Michaël B Zugaro.

Supplementary information

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    Supplementary Text and Figures

    Supplementary Figures 1–6 and Supplementary Methods

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DOI

https://doi.org/10.1038/nn.2384