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Structural biology: Mycobacterial ESX secrets revealed

Nature Microbiology volume 2, Article number: 17074 (2017) Cite this article

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Structural analysis of the mycobacterial ESX-5 secretion complex presents an important step towards understanding how the ESX type VII (T7) secretion systems can translocate a multitude of substrates — including virulence factors involved in pathogenesis — across the bacterial cell envelope.

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Figure 1: Speculative model for ESX-5 organization under resting and translocating conditions.

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Authors and Affiliations

  1. Tracy Palmer is in the Division of Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.,

    Tracy Palmer

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  1. Tracy Palmer
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Correspondence to Tracy Palmer.

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The author declares no competing financial interests.

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Palmer, T. Structural biology: Mycobacterial ESX secrets revealed. Nat Microbiol 2, 17074 (2017). https://doi.org/10.1038/nmicrobiol.2017.74

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