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Parasite physiology: No longer lost in translation

Nature Microbiology volume 2, Article number: 17055 (2017) Cite this article

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The antimalarial mefloquine has been used in the clinic for decades, yet its mode of action has remained elusive. Now, a study reports that the enantiomer (+)-mefloquine binds to the cytosolic ribosome of the major malaria parasite Plasmodium falciparum.

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Figure 1: Mefloquine binding to the P. falciparum cytoplasmic ribosome, Pf80S.

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Authors and Affiliations

  1. Jeremy Burrows is at the Medicines for Malaria Venture, Route de Pré Bois 20, 1215 Meyrin, Geneva 15, Switzerland.,

    Jeremy Burrows

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  1. Jeremy Burrows
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Correspondence to Jeremy Burrows.

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The author declares no competing financial interests.

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Burrows, J. Parasite physiology: No longer lost in translation. Nat Microbiol 2, 17055 (2017). https://doi.org/10.1038/nmicrobiol.2017.55

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