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Bacterial pathogenesis: Pathogenic bacteria attack RHIM

Attaching and effacing enteropathogenic Escherichia coli causes gastrointestinal inflammation and diarrhoea. In this issue of Nature Microbiology, Pearson and colleagues find that this pathology involves bacterial cleavage of a class of host cell death signal adaptors that encode a unique protein interaction motif called the RHIM.

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Figure 1: RHIM protein cleavage in EPEC infection.

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Correspondence to Francis Ka-Ming Chan.

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DeSouza-Vieira, T., Chan, FM. Bacterial pathogenesis: Pathogenic bacteria attack RHIM. Nat Microbiol 2, 17042 (2017). https://doi.org/10.1038/nmicrobiol.2017.42

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  • DOI: https://doi.org/10.1038/nmicrobiol.2017.42

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