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Host response: Inflammation promotes TB growth

Nature Microbiology volume 2, Article number: 17102 (2017) Cite this article

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Nitric oxide synthase has long been associated with control of Mycobacterium tuberculosis infection. However, new work reveals that instead of directing an antibacterial killing response, nitric oxide is critical for restraining granulocytic inflammation, which can provide a nutrient-rich niche for increased bacterial growth.

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Figure 1: Model for NO regulation of inflammatory responses during Mtb infection.

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  1. Christina L. Stallings is in the Department of Molecular Microbiology, Washington University School of Medicine, Box 8230, 660 South Euclid Avenue, St. Louis, Missouri 63110, USA.,

    Christina L. Stallings

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  1. Christina L. Stallings
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Correspondence to Christina L. Stallings.

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Stallings, C. Host response: Inflammation promotes TB growth. Nat Microbiol 2, 17102 (2017). https://doi.org/10.1038/nmicrobiol.2017.102

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