News and Views

Antimicrobial resistance: Survival by reversible resistance

Antibiotic therapy is a cornerstone of contemporary medicine. Resistance testing is the gold standard for selecting antibiotics, but in some cases they are surprisingly ineffective. A study now shows that pathogens can form a subset of cells which survive, and even continue to grow in the face of antibiotics.

  • Subscribe to Nature Microbiology for full access:

    $59

    Subscribe

  • Purchase article full text and PDF:

    $18

    Buy now

Additional access options:

Already a subscriber?  Log in  now or  Register  for online access.

References

  1. 1.

    Antimicrobial Resistance: Global Report on Surveillance (WHO, 2014).

  2. 2.

    Annu. Rev. Microbiol. 64, 357–372 (2010).

  3. 3.

    et al. Science 343, 204–208 (2014).

  4. 4.

    et al. PLoS Biol. 12, e1001793 (2014).

  5. 5.

    et al. Cell 158, 722–733 (2014).

  6. 6.

    et al. Curr. Biol. 24, 2000–2005 (2014).

  7. 7.

    et al. Nature Microbiol. 1, 16053 (2016).

  8. 8.

    , I& Drug Resist. Updat. 13, 132–138 (2010).

  9. 9.

    , , & Antimicrob. Agents Chemother. 59, 2780–2784 (2015).

  10. 10.

    et al. Science 339, 91–95 (2013).

  11. 11.

    et al. Nature 527, 323–328 (2015).

Download references

Author information

Affiliations

  1. Wolf-Dietrich Hardt is at the Institute of Microbiology and the Department of Biology of the Eidgenössissische Technische Hochschule ETH Zürich, Vladimir-Prelog Weg 4, 8093 Zurich, Switzerland.

    • Wolf-Dietrich Hardt

Authors

  1. Search for Wolf-Dietrich Hardt in:

Corresponding author

Correspondence to Wolf-Dietrich Hardt.