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Antimicrobial resistance: Survival by reversible resistance

Nature Microbiology volume 1, Article number: 16072 (2016) Cite this article

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Antibiotic therapy is a cornerstone of contemporary medicine. Resistance testing is the gold standard for selecting antibiotics, but in some cases they are surprisingly ineffective. A study now shows that pathogens can form a subset of cells which survive, and even continue to grow in the face of antibiotics.

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Figure 1: Clonal heteroresistance of E. cloacae in vitro (top) and during infection (bottom).

References

  1. Antimicrobial Resistance: Global Report on Surveillance (WHO, 2014).

  2. Lewis, K. Annu. Rev. Microbiol. 64, 357–372 (2010).

    Article  CAS  Google Scholar 

  3. Helaine, S. et al. Science 343, 204–208 (2014).

    Article  CAS  Google Scholar 

  4. Kaiser, P. et al. PLoS Biol. 12, e1001793 (2014).

    Article  Google Scholar 

  5. Claudi, B. et al. Cell 158, 722–733 (2014).

    Article  CAS  Google Scholar 

  6. Diard, M. et al. Curr. Biol. 24, 2000–2005 (2014).

    Article  CAS  Google Scholar 

  7. Band, V. I. et al. Nature Microbiol. 1, 16053 (2016).

    Article  CAS  Google Scholar 

  8. Falagas, M. E., Rafailidis, P. I& Matthaiou, D. K. Drug Resist. Updat. 13, 132–138 (2010).

    Article  CAS  Google Scholar 

  9. Jayol, A., Nordmann, P., Brink, A. & Poirel, L. Antimicrob. Agents Chemother. 59, 2780–2784 (2015).

    Article  CAS  Google Scholar 

  10. Wakamoto, Y. et al. Science 339, 91–95 (2013).

    Article  CAS  Google Scholar 

  11. Lehar, S. M. et al. Nature 527, 323–328 (2015).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Wolf-Dietrich Hardt is at the Institute of Microbiology and the Department of Biology of the Eidgenössissische Technische Hochschule ETH Zürich, Vladimir-Prelog Weg 4, 8093 Zurich, Switzerland.,

    Wolf-Dietrich Hardt

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  1. Wolf-Dietrich Hardt
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Correspondence to Wolf-Dietrich Hardt.

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Hardt, WD. Antimicrobial resistance: Survival by reversible resistance. Nat Microbiol 1, 16072 (2016). https://doi.org/10.1038/nmicrobiol.2016.72

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  • DOI: https://doi.org/10.1038/nmicrobiol.2016.72

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