Whole genome sequencing is often used to determine the presence of known antimicrobial resistance genes and identify new resistance mechanisms. However, without phenotypic confirmation of resistance, caution needs to be taken in attributing relevance to any genes hitherto not shown to confer drug resistance.
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References
Loman, N. J. & Pallen, M. Nature Rev. Microbiol. 13, 787–794 (2015).
Goldberg, B. et al. mBio 6 e01888–15 (2015).
Koser, C. U. et al. Trends Genet. 30, 401–407 (2014).
De Been, M. et al. PLOS Genet. 10, e1004776 (2014).
McArthur, A. G. et al. Antimicrob. Agents Chemother. 57, 3348–3357 (2013).
Blair, J. M. et al. Proc. Natl Acad. Sci. USA 112, 3511–3516 (2015).
Baylay, A. J. & Piddock, L. J. V. J. Antimicrob. Chemother. 70, 670–679 (2015).
Billal, D. S. et al. BMC Genom. 12, 512 (2011).
Croucher, N. J. et al. PLOS Genet. 9, e1003868 (2013).
Baylay, A. J. & Piddock, L. J. V. Antimicrob. Agents Chemother. 59, 3098–3108 (2015).
Sandegren, L. & Andersson, D. Nature Rev. Microbiol. 7, 578–588 (2009).
Chewapreecha, C. et al. PLOS Genet. 10, e1004547 (2014).
Livermore, D. M. et al. J. Antimicrob. Chemother. 59, 165–174 (2006).
Earle, S. G. et al. Nature Microbiol. 1, 16041 (2016).
Andersson, D. I. & Hughes, D. Nature Rev. Microbiol. 12, 465–478 (2014).
Koch, R. Beitr. Biol. Pflanz. 2, 277–310 (1876).
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Piddock, L. Assess drug-resistance phenotypes, not just genotypes. Nat Microbiol 1, 16120 (2016). https://doi.org/10.1038/nmicrobiol.2016.120
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DOI: https://doi.org/10.1038/nmicrobiol.2016.120
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