Mice raised under specific pathogen-free conditions in a lab do not model the natural exposure of animals and humans to environmental commensals and pathogens. Now, two studies show that exposing mice to their natural environment, or infecting them with specific pathogens, results in an immune system that better resembles that of adult humans.
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References
Beura, L. K. et al. Nature 532, 512–516 (2016).
Reese, T. A. et al. Cell Host Microbe 19, 1–7 (2016).
Sallusto, F., Lanzavecchia, A., Araki, K. & Ahmed, R. Immunity 33 451–463 (2010).
Mueller, S. N., Gebhardt, T., Carbone, F. R. & Heath, W. R. Annu. Rev. Immunol. 31, 137–161 (2013).
Casanova, J.-L. & Abel, L. J. Exp. Med. 202, 197–201 (2005).
Netea, M. G. et al. Science 352, aaf1098 (2016).
Welsh, R. M., Che, J. W., Brehm, M. A. & Selin, L. K. Immunol. Rev. 235, 244–266 (2010).
Lobigs, M. & Diamond, M. S. Expert Rev. Vaccines 11, 177–187 (2012).
Guo, L., Junttila, I. S. & Paul, W. E. Trends Immunol 33, 598–606 (2012).
Spits, H. & Cupedo, T. Annu. Rev. Immunol. 30, 647–675 (2012).
Chandra, S. & Kronenberg, M. Adv. Immunol. 127, 145–201 (2015).
Honda, K. & Littman, D. R. Annu. Rev. Immunol. 30, 759–795 (2012).
Hooper, L. V., Littman, D. R. & Macpherson, A. J. Science 336, 1268–1273 (2012).
Okada, H., Kuhn, C., Feillet, H. & Bach, J. F. Clin. Exp. Immunol. 160, 1–9 (2010).
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Sallusto, F. Host response: Mice and humans in the bubble. Nat Microbiol 1, 16105 (2016). https://doi.org/10.1038/nmicrobiol.2016.105
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DOI: https://doi.org/10.1038/nmicrobiol.2016.105