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Viral infection: A key host receptor for AAV

A transmembrane protein receptor that is critical for adeno-associated virus infection has been identified through an unbiased, genome-wide screen. Its role in viral entry could potentially be harnessed to develop enhanced gene therapy vectors and better animal models of human disease.

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Figure 1: The role of AAVR in AAV cellular entry.

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Correspondence to David V. Schaffer.

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Sun, S., Schaffer, D. Viral infection: A key host receptor for AAV. Nat Microbiol 1, 15027 (2016). https://doi.org/10.1038/nmicrobiol.2015.27

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