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Optogenetics meets optical wavefront shaping

Nature Methods volume 7, pages 798–799 (2010)Cite this article

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Optogenetic stimulation by ultrashort laser pulses could allow neural circuits in the living brain to be probed with cellular resolution, despite pervasive light scattering. Now sophisticated new multiphoton stimulation systems that strike a better balance between lateral and axial resolution help realize this potential by matching the illumination volume to the soma's dimensions.

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Figure 1: The challenge of optogenetic multiphoton stimulation.

References

  1. Zhang, F. et al. Nat. Protoc. 5, 439–456 (2010).

    Article  CAS  Google Scholar 

  2. Rickgauer, J. P. & Tank, D.W. Proc. Natl. Acad. Sci. USA 106, 15025–15030 (2009).

    Article  CAS  Google Scholar 

  3. Shoham, S., O'Connor, D.H., Sarkisov, D.V. & Wang, S.S. Nat. Methods 2, 837–843 (2005).

    Article  CAS  Google Scholar 

  4. Nikolenko, V., Poskanzer, K. E. & Yuste, R. Nat. Methods 4, 943–950 (2007).

    Article  CAS  Google Scholar 

  5. Grewe, B.F., Langer, D., Kasper, H., Kampa, B.M. & Helmchen, F. Nat. Methods 7, 399–405 (2010).

    Article  CAS  Google Scholar 

  6. Papagiakoumou, E. et al. Nat. Methods 7, 848–854 (2010).

    Article  CAS  Google Scholar 

  7. Andrasfalvy, B.K., Zemelman, B.V., Tang, J. & Vaziri, A. Proc. Natl. Acad. Sci. USA 107, 11981–11986 (2010).

    Article  CAS  Google Scholar 

  8. Glückstad, J. Opt. Commun. 130, 225–230 (1996).

    Article  Google Scholar 

  9. Oron, D., Tal, E. & Silberberg, Y. Opt. Express 13, 1468–1476 (2005).

    Article  Google Scholar 

  10. Lutz, C. et al. Nat. Methods 5, 821–827 (2008).

    Article  CAS  Google Scholar 

  11. Golan, L., Reutsky, I., Farah, N. & Shoham, S. J. Neural Eng. 6, 066004 (2009).

    Article  CAS  Google Scholar 

  12. Jesacher, A., Maurer, C., Schwaighofer, A., Bernet, S. & Ritsch-Marte, M. Opt. Express 16, 2597–2603 (2008).

    Article  Google Scholar 

Download references

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  1. Shy Shoham is in the Faculty of Biomedical Engineering, The Technion, Israel Institute of Technology, Haifa, Israel.,

    Shy Shoham

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  1. Shy Shoham
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Correspondence to Shy Shoham.

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Shoham, S. Optogenetics meets optical wavefront shaping. Nat Methods 7, 798–799 (2010). https://doi.org/10.1038/nmeth1010-798

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