The adaptation of the protein misfolding cyclic amplification assay (PMCA) to use recombinant hamster prion protein (PrP) as a substrate shows promise for both basic research applications and clinical diagnostic assays.
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Aguzzi, A. Prion biology: the quest for the test. Nat Methods 4, 614–616 (2007). https://doi.org/10.1038/nmeth0807-614
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DOI: https://doi.org/10.1038/nmeth0807-614
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