Although new super-resolution imaging techniques provide valuable biological insights, some applications, such as determining the organization of neural projections in the brain, are better served by comprehensive imaging of very large samples at lower resolution.
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References
- 1.
Donnert, G. et al. Biophys J.; published online 16 February 2007.
- 2.
Gustafsson, M.G. Proc. Natl. Acad. Sci. USA 102, 13081–13086 (2005).
- 3.
Betzig, E. et al. Science 313, 1642–1645 (2006).
- 4.
Rust, M.J., Bates, M. & Zhuang, X. Nat. Methods 3, 793–795 (2006).
- 5.
Denk, W. & Horstmann, H. PLoS Biol. 2, e329 (2004).
- 6.
Verveer, P.J. et al. Nat. Methods 4, 311–313 (2007).
- 7.
Sharpe, J. et al. Science 296, 541–545 (2002).
- 8.
Huisken, J., Swoger, J., Del Bene, F., Wittbrodt, J. & Stelzer, E.H. Science 305, 1007–1009 (2004).
- 9.
Dodt, H.-U. et al. Nat. Methods 4, 331–336 (2007).
- 10.
Spalteholz, W. Über das Durchsichtigmachen von menschlichen und tierischen Präparaten. (S. Hierzel, Leipzig, 1914).
- 11.
Siedentopf, H. & Zsigmondy, R. Annalen der Physik 10, 1–39 (1903).
- 12.
Feng, G. et al. Neuron 28, 41–51 (2000).
- 13.
Scott, E.K. et al. Nat. Methods 4, 323–326 (2007).
- 14.
Lein, E.S. et al. Nature 445, 168–176 (2007).
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Affiliations
Narayanan Kasthuri and Jeff W. Lichtman are in the Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA. jlichtman@mcb.harvard.edu and bobby.kasthuri@gmail.com
- Narayanan Kasthuri
- & Jeff W Lichtman
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Competing interests
The authors declare no competing financial interests.
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