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References
de Groot, B.L. et al. Proteins Struct. Funct. Genet. 29, 240–251 (1997).
Sitkoff, D., Sharp, K.A. & Honig, B. J. Phys. Chem. 98, 1978–1988 (1994).
Guerois, R., Nielsen, J.E. & Serrano, L. J. Mol. Biol. 320, 369–387 (2002).
Yin, S., Ding, F. & Dokholyan, N.V. Nat. Methods 4, 466–467 (2007).
Kortemme, T. & Baker, D. Proc. Natl. Acad. Sci. USA 99, 14116–14121 (2002).
Reichmann, D. et al. Proc. Natl. Acad. Sci. USA 102, 57–62 (2005).
Åqvist, J., Medina, C. & Samuelsson, J.E. Protein Eng. 7, 385–391 (1994).
Srinivasan, J., Cheatham, T.E., Cieplak, P., Kollman, P.A. & Case, D.A. J. Am. Chem. Soc. 120, 9401–9409 (1998).
Acknowledgements
We thank J. Schymkowitz for help with FoldX. A.B., C.M.B., B.L.G. and R.A.B. acknowledge support by the Deutsche Forschungsgemeinschaft (BO 2963/1-1, GR 2079/4-1, BIZ 4/1). Part of the work was supported by the Swiss National Center for Competence in Research in Structural Biology (R.A.B. and A.C.).
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Benedix, A., Becker, C., de Groot, B. et al. Predicting free energy changes using structural ensembles. Nat Methods 6, 3–4 (2009). https://doi.org/10.1038/nmeth0109-3
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DOI: https://doi.org/10.1038/nmeth0109-3
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